I am having more than a few problems with Leopard.
1) My FCP will quit in the middle of exports to QT
2) All of my ROXIO products - Toast-Jam-Crunch-CD Spin Doctor, have Audio Distortion and Artifacts
3) I have a horizontal video noise line from time to time on my display
4) 3rd party apps like Quick Verse are not working
5) Many Many Lock Ups and Freeze ups when running SPACES and multi-Apps at the same time.
6) One of my External Wiebetech Silver SATA V RAID drives had a permanent failure after Leopard install
7) iTunes freezes at times.
I did a Clean Instal after another drive started acting funny. I have a Mac Pro with four 1TB Hitachi internals and about 10 TB external hooked up.