The best way to de-install an application is to run the de-installer that came with it. If no de-installer was included, then you can go to the Applications folder, find the program, drag it to the trash, and empty the trash. However, while that's all you need to do for some applications, with others that may not remove additional support files/drivers that may have been installed -- in those cases I'd consult the documentation for the application for instructions on how to remove all components.
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